GLP-1相关论文
目的:二肽基肽酶-4（Dipeptidyl peptidase-4,DPP-4）抑制剂是近年来治疗2型糖尿病（Type 2 diabetes mellitus,T2DM）的新型靶点药物,可通......
研究目的:（1）基于16S rDNA测序比较健康女性与多囊卵巢综合征（PCOS）患者肠道菌群的结构、丰度及多样性差异,总结PCOS患者肠道菌群的特......
高血压是全世界最常见的慢性非传染性疾病，也是诱发心脑血管疾病最重要的危险因素。目前高血压治疗达标控制率不足50%,在很大程度上......
目的:本课题观察柴胡桂枝干姜汤治疗肝郁脾虚型肠易激综合征（IBS-D）患者的临床疗效,通过对比患者的疗效、症状积分、血浆GLP-1的含量......
背景和研究目的糖尿病是一组以高血糖为特点的代谢性疾病。近年来,全球糖尿病患病率呈逐渐攀升趋势,2019年,中国患者数已达1.164亿......
降低禽类啄羽行为发生,减缓禽类养殖业压力,探索啄羽行为发生的机理,促进动物福利养殖,是目前学术研究的热点。番鸭因其肉质好、有......
目的 研究GLP-1通过调控mTOR信号通路诱导的自噬对糖尿病大鼠视网膜病变是否存在保护作用。方法 建立符合要求的糖尿病视网膜病变......
胰高血糖素样肽-1(GLP-1)是目前认为最重要的肠促胰岛素,临床上主要用于降糖、减轻体重等适应症.其短效及长效药物均有已上市品规,......
马齿苋（Portulaca oleracea L.）用于治疗糖尿病早有记载。现代药理学和临床研究表明,马齿苋的降糖作用与GLP-1相似,都具有促进胰岛素......
目的观察GLP-1受体激动剂艾塞那肽干预对脑缺血再灌注大鼠炎症反应的影响,探讨艾塞那肽的神经保护作用,以期为缺血性脑卒中的治疗......
目的:观察利拉鲁肽联合恩格列净对初诊超重/肥胖2型糖尿病患者β细胞分泌功能及胰岛素抵抗的疗效.方法:选取初诊的超重/肥胖2型糖......
2型糖尿病是人类健康的重要威胁,病发过程会伴随胰岛素抵抗和β细胞功能障碍。胰高血糖素样肽-1（glucagon like peptide-1,GLP-1）是......
目的:中国是世界上人口最多发国家,同时也是糖尿病（diabetes mellitus,DM）患者最多的国家,目前,我国糖尿病的患病率还在急剧增加,与......
研究背景糖尿病是一种常见的慢性疾病,因其发病率高,并发症对机体损伤严重,已成为世界第三大非传染性疾病,患者中约90%以上为2型糖......
第一章 利拉鲁肽对糖尿病小鼠糖代谢及肠道菌群的研究目的:分析利拉鲁肽对db/db小鼠进食量、体重、糖脂代谢以及肠道菌群产生的影......
The relationship between diabetes mellitus and Parkinson\'s disease has been described in several epidemiological stud......
2 型糖尿病作为一种复杂的代谢疾病，已经严重影响人类健康。益生菌可以调节肠道L 细胞分泌胰升血糖素样肽(GLP-1)，改善胰岛素抵抗，增......
Endothelin-converting enzyme-1 regulates the re-sensitisation of signalling by the glucagon-like pep
Aim: Endothelin-converting enzyme-1 (ECE-1) may regulate trafficking of internalized GPCRs by degrading peptide ligands ......
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GLP-1 analogue CJC-1131 Rescues Spatial Cognition and Synaptic Plasticity of Rats from Aβ1-42-induce
Although the amyloid β protein (Aβ) aggregated in the brain has been recognized as one of the main pathological charac......
Aims/hypothesis: Glucagon-like peptide(GLP-1),an intestinal incretin produced in L-cells through proglucagon processing,......
The relationship between secretions of GLP-1 and insulin after oral glucose load in Japanese subject
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会议
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Glucagon-like peptide 1 improves vascular remodeling by down-regulating matrix metalloproteinase 1 e
As an incretin used to treat type 2 diabetes,glucagon-like peptide 1(GLP-1)improves cardiovascular diseases by regulatin......
Involvement of gut microbiota in the association between GLP-1/GLP-1 receptor expression and gastroi
Background: Microbiota in the gut is known to play a pivotal role in host physiology by interacting with the immune and ......
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目的探讨袖状胃切除术附加改良空回肠旁路术改善GK大鼠血糖水平的机制。方法按照随机数表法，将28只GK大鼠分为袖状胃切除附加改良空......
A Functional Inhibitory Role of Habenular Glucagon-Like Peptide-1 (GLP-1) in Forebrain Reward Signal
There is emerging evidence implicating glucagon-like peptide-1 (GLP-1) in reward, including palatable food reinforcement......
目的 观察葛根芩连汤(GGQL)对NCI-H716细胞胰高血糖素样肽-1(GLP-1)、G蛋白偶联受体119(GPR119)蛋白及基因表达的影响,从而明确其......
Notoginsenoside Ft1 acts as a TGR5 agonist but FXR antagonist to alleviate high fat diet-induced obe
Obesity and its associated complications are highly related to a current public health crisis around the world.A growing......
Mitochondrial protein IF1 is a potential regulator of glucagon-like peptide (GLP-1)secretion functio
IF1 (ATPIF1) is a nuclear DNA-encoded mitochondrial protein whose activity is inhibition of the F1Fo-ATP synthase to con......
Glucagon-like peptide 1 stimulates insulin secretion via inhibiting RhoAROCK signaling and disassemb
Aims/hypothesis chronic hyperglycemia results in impaired glucose-stimulated insulin secretion (GSIS).Glucagon-Like ......
Effects of monosodium glutamate supplementation on blood lipid, amino acid and hormone and colonic o
Monosodium glutamate (MSG) is currently used as a flavor enhancer in human nutrition.Supplemental glutamate may impa......
G-protein coupled receptors(GPCRs)compromise the largest membrane protein superfamily which play vital roles in physiolo......
目的:探讨下丘脑室旁核(hypothalamic paraventricular nucleus,PVN)注射GLP-1(胰高血糖素样肽-1)对糖尿病大鼠胃排空的影响及机制......
GLP-1主要由正常人体肠道L细胞和中枢神经元分泌的,主要通过调控胰岛素和胰高血糖素的分泌,延缓胃的排空和调节胰岛素的敏感性等途......
2型糖尿病是以胰岛素抵抗伴胰岛素分泌不足导致高血糖为特征的代谢性疾病。在2型糖尿病发病人群中,80%以上的患者都伴有超重或肥胖......
目的观察回肠转位术(ileal transposition,IT)对非肥胖型2型糖尿病GK大鼠的血糖及胰高血糖素样肽-1(glucagon-like peptide-1,GLP-......
